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Mission

Phage therapy (PT) is also called bacteriophage therapy. It uses viruses to treat bacterial infections. Bacterial viruses are called phages or bacteriophages. They only attack bacteria; phages are harmless to people, animals, and plants.

Ideas

Bacteriophages are the natural enemies of bacteria. The word bacteriophage means “bacteria eater.” They’re found in soil, sewage, water, and other places bacteria live. These viruses help keep bacteria growth in check in nature.

Technology

Phage therapy might sound new, but it has been used for 100 years. However, the treatment isn’t well known. More research is needed on bacteriophages. This therapy for disease-causing bacteria may be a useful alternative to antibiotics.

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News & events

First human transplant of a genetically modified pig kidney performed

The kidney transplanted in Boston came from a pig created by eGenesis of Cambridge, Mass. The eGenesis pigs are bred with 69 genetic modifications to prepare organs for human transplantation. The changes…

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Novel treatment based on gene editing safely and effectively removes HIV-like virus from genomes of non-human primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV -- a virus related to the AIDS-causing agent HIV -- from the genomes of non-human primates, scientists now…

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CRISPR/Cas9 as a therapeutic tool for triple negative breast cancer: from bench to clinics

Clustered regularly interspaced short palindromic repeats (CRISPR) is a third-generation genome editing method that has revolutionized the world with its high throughput results. It has been used in the treatment of various…

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Gene editing makes bacteria-killing viruses even more deadly

Broad-spectrum antibiotics are akin to nuclear bombs, obliterating every prokaryote they meet. They're effective at eliminating pathogens, sure, but they're not so great for maintaining a healthy microbiome. Ideally, we need precision…

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CRISPR cancer trial success paves the way for personalized treatments

‘Most complicated therapy ever’ tailors bespoke, genome-edited immune cells to attack tumors. A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they…

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Synthego Raises $200 Million to Accelerate the Field of CRISPR-Based Medicines from Early-Phase Research to the Clinic

Synthego, the genome engineering company, today announced it has raised $200 million of growth capital, including a Series E financing led by Perceptive Advisors. Also participating in the round were new investors…

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Bacteriophages a key to getting the musty smell out of tap water

Actinomycetes are common soil and other organic matter, and can grow on water pipes.

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Lettuce Developed With CRISPR/Cas Gene Editing Tech Boosts Nutrients

Classic breeding methods such as mutagenesis or hybridization have been the foundation for plant breeding, where spontaneous mutations and recombination are utilized for plant genetic improvement. While random mutagenesis can create many…

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Quotable and Notable

“CRISPR has become a powerful discovery tool, and the field is now at an inflection point. The promise of translating insights into clinical applications to treat a myriad of serious diseases, including cancer and genetic disorders, is within reach. With Synthego’s full stack of proprietary platforms, clinical-grade manufacturing capabilities, and…
Paul Dabrowski co-founder and CEO of Synthego
“Everyone is thinking about the therapeutic application of CRISPR, but sometimes we forget that the first thing that CRISPR does is searching.”  ~ Kiana Aran, Assistant Professor, Keck Graduate Institute
Kiana Aran
“The introduction of gene editing and CRISPR-based approaches in the clinic will likely begin with T-cell therapies because of the relative ease of T-cell manipulation and transduction, combined with the relevance of T-cell therapies to a large number of disorders, including cancer and others.”  ~ Dr. Michel Sadelain, MD, Ph.D.
Dr. Michel Sadelain, MD, PHD
“CRISPR-Cas9 is like molecular scissors, while base editors are like pencils...For some applications, scissors are the best tool for the job, while for other applications, such as fixing a single letter in DNA, a pencil is best.” ~ Dr. David Liu
Dr. David Liu
“CRISPR-GO could provide an opportunity to answer that question by enabling us to target, move and relocate very specific stretches of DNA, and see how their new placements in the nucleus change how they function.” ~ Stanley Qi Lab
Stanley Qi Lab
“I see this as an outstanding initiative to attract more talented people to biotechnologies and support the scientists in the field. At the same time, I could not be more proud that my life’s work might inspire other young scientists to aim high in their paths towards new discoveries.”  ~…
Virginijus Šikšnys
“I think it’s good to be reminded that we are in this very fortunate position to be able to make a positive change, and we shouldn’t screw it up.” ~ Dr. Feng Zhang
Dr. Feng Zhang

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HOW PHAGE THERAPY WORKS
Bacteriophages kill bacteria by making them burst or lyse. This happens when the virus binds to the bacteria. A virus infects the bacteria by injecting its genes (DNA or RNA).
PHAGE THERAPY vs. ANTIBIOTICS
Antibiotics are also called anti-bacterials. They’re the most common type of treatment for bacterial infections. Antibiotics are chemicals or drugs that destroy bacteria in your body.
ANTIBIOTIC ATTACK
This means they can kill both bad and good bacteria in your body. Your body needs certain kinds of bacteria to help you digest food, make some nutrients, and keep you healthy.
ANTIBIOTIC SUPER BUGS
This means that instead of stopping, some bacteria become resistant or immune to antibiotic treatment. Resistance happens when bacteria evolve or change to become stronger than the antibiotics.
PHAGE THERAPY BENEFITS
Just as there are many kinds of bacteria, there are several types of bacteriophages. But each kind of phage will only attack a certain bacterium. It won’t infect other kinds of bacteria.
PHAGE THERAPY APPROVAL
Phage therapy isn’t yet approved for people in the United States or in Europe. There has been experimental phage use in a few rare cases only.

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